Ебола: Разлика между версии

 

Към септември 2014 няма одобрена [[ваксина]] за употреба върху хора.<ref name=WHOSept2014/><ref>{{en икона}} {{cite web|title=FDA warns consumers about fraudulent Ebola treatment Но усилено се работи по откриването ѝ : http://www.vesti.bg/sviat/ruski-zdraven-ministyr-imame-vaksina-sreshtu-ebola-6021656products|url=http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm410086.htm|accessdate=20 август 2014}}</ref> Възлагани са надежди, че такава може да се появи през ноември 2014.<ref name=WHOSept2014>{{en икона}} {{cite web |title=Statement on the WHO Consultation on potential Ebola therapies and vaccines |url=http://www.who.int/mediacentre/news/statements/2014/ebola-therapies-consultation/en/ |website=WHO |accessdate=1 октомври 2014 |date=5 септември 2014}}</ref> Най-обещаващи кандидати са [[ДНК ваксинация|ДНК ваксини]]<ref name="Xu1998">{{en икона}} {{cite journal | author = Xu L, Sanchez A, Yang Z, Zaki SR, Nabel EG, Nichol ST, Nabel GJ | title = Immunization for Ebola virus infection | journal = Nature Medicine | volume = 4 | issue = 1 | pages = 37–42 |date=януари 1998 | pmid = 9427604 | doi = 10.1038/nm0198-037 }}</ref> или ваксини, извлечени от [[Adenoviridae|аденовируси]] <ref name="Sullivan2003">{{en икона}} {{cite journal | author = Sullivan NJ, Geisbert TW, Geisbert JB, Xu L, Yang ZY, Roederer M, Koup RA, Jahrling PB, Nabel GJ | title = Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates |journal=Nature |volume=424 |issue=6949 |pages=681–684 |date=7 август 2003 | pmid = 12904795 | doi = 10.1038/nature01876 }}</ref>, [[везикуларен стоматитен вирус|везикуларен стоматитен Индиана вирус (ВСИВ)]] <ref name=Geisbert1-2008>{{en икона}} {{cite journal | author = Geisbert TW, Daddario-Dicaprio KM, Geisbert JB, Reed DS, Feldmann F, Grolla A, Ströher U, Fritz EA, Hensley LE, Jones SM, Feldmann H | title = Vesicular stomatitis virus-based vaccines protect nonhuman primates against aerosol challenge with Ebola and Marburg viruses | journal = Vaccine | volume = 26 | issue = 52 | pages = 6894–6900 |date=9 декември 2008 | pmid = 18930776 | pmc = 3398796 | doi = 10.1016/j.vaccine.2008.09.082 }}</ref><ref name=Geisbert2-2008>{{en икона}} {{cite journal | author = Geisbert TW, Daddario-Dicaprio KM, Lewis MG, Geisbert JB, Grolla A, Leung A, Paragas J, Matthias L, Smith MA, Jones SM, Hensley LE, Feldmann H, Jahrling PB | title = Vesicular stomatitis virus-based Ebola vaccine is well-tolerated and protects immunocompromised nonhuman primates | journal = PLoS Pathogens | volume = 4 | issue = 11 | pages = e1000225 |date=ноември 2008 | pmid = 19043556 | pmc = 2582959 | doi = 10.1371/journal.ppat.1000225 | editor1-last = Kawaoka | editor1-first = Yoshihiro }}</ref><ref name=Geisbert2009>{{en икона}} {{cite journal | author = Geisbert TW, Geisbert JB, Leung A, Daddario-DiCaprio KM, Hensley LE, Grolla A, Feldmann H | title = Single-injection vaccine protects nonhuman primates against infection with Marburg virus and three species of Ebola virus | journal = Journal of Virology | volume = 83 | issue = 14 | pages = 7296–7304 | year = 2009 | pmid = 19386702 | pmc = 2704787 | doi = 10.1128/JVI.00561-09 }}</ref> или [[вирусоподобна частица|филовирусоподобни частици (ВПЧ)]] <ref name=Warfield2007>{{en икона}} {{cite journal | author = Warfield KL, Swenson DL, Olinger GG, Kalina WV, Aman MJ, Bavari S | title = Ebola virus‐like particle–based vaccine protects nonhuman primates against lethal ebola virus challenge | journal = The Journal of Infectious Diseases | volume = 196 | pages = S430–S437 | year = 2007 | pmid = 17940980 | doi = 10.1086/520583 }}</ref>, тъй като тези кандидати могат да предпазват нечовекоподобни примати от заболяване индуцирано от ебола вирус. ДНС ваксините, аденовирусно базираните максини и ВСИВ-базираните максини са навлезли в клинични изследвания <ref name="Oplinger">{{en икона}} {{Cite book|last=Oplinger|first=Anne A.|date=18 November 2003|title=NIAID Ebola vaccine enters human trial|url=http://news.bio-medicine.org/medicine-news-2/NIAID-Ebola-vaccine-enters-human-trial-4881-1/|publisher=Bio-Medicine}}</ref><ref name="NIAIDVaccineDevelopment">{{en икона}} {{Cite press release |title=Ebola/Marburg vaccine development |publisher=National Institute of Allergy and Infectious Diseases |date=15 септември 2008 |url=http://www3.niaid.nih.gov/topics/ebolaMarburg/default.htm }}</ref><ref name=Martin2006>{{en икона}} {{cite journal | author = Martin JE, Sullivan NJ, Enama ME, Gordon IJ, Roederer M, Koup RA, Bailer RT, Chakrabarti BK, Bailey MA, Gomez PL, Andrews CA, Moodie Z, Gu L, Stein JA, Nabel GJ, Graham BS | title = A DNA vaccine for Ebola virus is safe and immunogenic in a phase I clinical trial | journal = Clinical and Vaccine Immunology | volume = 13 | issue = 11 | pages = 1267–1277 |date=ноември 2006 | pmid = 16988008 | pmc = 1656552 | doi = 10.1128/CVI.00162-06 | author17 = the VRC 204 Study Team1‡ }}</ref><ref>{{en икона}} {{Cite news |last=Bush |first=L |date=21 април 2005|title=Crucell and NIH sign Ebola vaccine manufacturing contract |url=http://www.pharmtech.com/pharmtech/Formulation+Article/Crucell-and-NIH-Sign-Ebola-Vaccine-Manufacturing-C/ArticleStandard/Article/detail/157790?contextCategoryId=10448 |work=Pharmaceutical Technology |volume=29 |page=28|ref=harv}}</ref>

 

== Източници ==