Бял дроб: Разлика между версии

* Поддържа стерилността на организма благодарение на производството на слуз, съдържаща антимикробни съединения.<ref>{{Cite journal|author=Travis SM, Conway BA, Zabner J, ''et al.'' |title=Activity of abundant antimicrobials of the human airway |journal=American Journal of Respiratory Cell and Molecular Biology |volume=20 |issue=5 |pages=872 – 9 |year=1999 |month=May |pmid=10226057 |url=http://ajrcmb.atsjournals.org/cgi/pmidlookup?view=long&pmid=10226057}}</ref> Слузта съдържа [[гликопротеин]]и, в т.ч. [[муцин]], [[лактоферин]],<ref>{{Cite journal|author=Rogan MP, Taggart CC, Greene CM, Murphy PG, O'Neill SJ, McElvaney NG |title=Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis |journal=The Journal of Infectious Diseases |volume=190 |issue=7 |pages=1245 – 53 |year=2004 |month=October |pmid=15346334 |doi=10.1086/423821}}</ref> [[лизозим]], [[лактопероксидаза]].<ref>{{Cite journal|author=Wijkstrom-Frei C, El-Chemaly S, Ali-Rachedi R, ''et al.'' |title=Lactoperoxidase and human airway host defense |journal=American Journal of Respiratory Cell and Molecular Biology |volume=29 |issue=2 |pages=206 – 12 |year=2003 |month=August |pmid=12626341 |doi=10.1165/rcmb.2002-0152OC}}</ref><ref>{{Cite journal|author=Conner GE, Salathe M, Forteza R |title=Lactoperoxidase and hydrogen peroxide metabolism in the airway |journal=American Journal of Respiratory and Critical Care Medicine |volume=166 |issue=12 Pt 2 |pages=S57–61 |year=2002 |month=December |pmid=12471090 |doi=10.1164/rccm.2206018}}</ref> В секретът се открива още [[тироидна оксидаза]]<ref>{{Cite journal|author=Fischer H |title=Mechanisms and Function of DUOX in Epithelia of the Lung |journal=Antioxidants & Redox Signaling |volume=11 |issue=10 |pages=2453 – 65 |year=2009 |month=October |pmid=19358684 |doi=10.1089/ARS.2009.2558 |pmc=2823369}}</ref><ref>{{Cite journal|author=Rada B, Leto TL |title=Oxidative innate immune defenses by Nox/Duox family NADPH Oxidases |journal=Contributions to Microbiology |volume=15 |pages=164 – 87 |year=2008 |pmid=18511861 |pmc=2776633 |doi=10.1159/000136357|series=Contributions to Microbiology|isbn=978-3-8055-8548-4}}</ref><ref>{{Cite journal|author=Rada B, Lekstrom K, Damian S, Dupuy C, Leto TL |title=The Pseudomonas toxin pyocyanin inhibits the Dual oxidase-based antimicrobial system as it imposes oxidative stress on airway epithelial cells |journal=Journal of Immunology |volume=181 |issue=7 |pages=4883 – 93 |year=2008 |month=October |pmid=18802092 |pmc=2776642 |url=http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=18802092}}</ref> протеини произвеждащи водороден пероксид, който пречи на микробния синтез. Тази функция не се изпълнява при пациенти болни от [[муковисцидоза]].<ref>{{Cite journal|author=Moskwa P, Lorentzen D, Excoffon KJ, ''et al.'' |title=A Novel Host Defense System of Airways Is Defective in Cystic Fibrosis |journal=American Journal of Respiratory and Critical Care Medicine |volume=175 |issue=2 |pages=174 – 83 |year=2007 |month=Januaryянуари |pmid=17082494 |pmc=2720149 |doi=10.1164/rccm.200607-1029OC}}</ref><ref>{{Cite journal|author=Conner GE, Wijkstrom-Frei C, Randell SH, Fernandez VE, Salathe M |title=The Lactoperoxidase System Links Anion Transport To Host Defense in Cystic Fibrosis |journal=FEBS Letters |volume=581 |issue=2 |pages=271 – 8 |year=2007 |month=Januaryянуари |pmid=17204267 |pmc=1851694 |doi=10.1016/j.febslet.2006.12.025}}</ref>